Absorcion rapida y extensa baja upp rapida y amplia distribucion lcr y otros. Benznidazole is an antibiotic that is used to treat chagas disease in children ages 2 through 12 years chagas disease also called american trypanosomiasis is an infection caused by a parasite common to the areas of south america, central america and mexico. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pdf effects of buthionine sulfoximine nifurtimox and. Pdf in vitro susceptibility of trypanosoma cruzi strains from. Pdf the current chemotherapy for chagas disease is unsatisfactory with only two drugs. Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with trypanosoma cruzi, commonly referred to as chagas disease. Treatment is strongly recommended for adults up to 50 years old with chronic infection who do not already have advanced cardiomyopathy. Juan rosasguzman, juan rosassaucedo, alma rosa jacqueline romerogarcia. Benznidazole tablets usual adult and adolescent dose trypanosomiasis, american 1. Though rare, chagas disease can significantly impact the lives of children who become infected with the trypanosoma cruzi parasite. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda. Indications for treatment of chagas disease in immunocompetent patients.
Experimental benznidazole treatment of trypanosoma cruzi ii strains isolated. Benznidazole is a 2nitroimidazole trypanocidal agent that was introduced in 1971 for the treatment of trypanosoma cruzi infectioni. Chagas disease is an infectious disease caused by a parasite. Benznidazole tablets are white round tablets each containing 12. Benznidazole is a yellowish, practically crystalline powder that is practically insoluble in water, sparingly soluble in acetone and ethanol, and slightly soluble in methanol. After removing the plate from the chromatographic chamber, allow it to dry in air until the solvents have evaporated, and heat at 110 c for 10 minutes. A small study assessing the cytogenetic effect of benznidazole in 14 patients aged 11 months to 11 years with chagas disease has shown a twofold increase in chromosomal aberrations ca. Bmicroglobulina urinaria pruebas neuroconductuales cognitivas.
Clinical and pharmacological profile of benznidazole for. Benznidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of chagas disease. Antiparasitic treatment is indicated for all cases of acute or reactivated chagas disease and for chronic t. Currently, only benznidazole bzn and nifurtimox are recognized by the world health organization as effective drugs for treatment of cd. Benznidazole tablets are the first fdaapproved treatment for chagas disease in children 2 to 12 years of age 1.